Secret: plant "gold" extraction technology!


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Just saw this title, I believe you will be surprised, how can there be "gold" in the plant? In fact, the "gold" mentioned by the editor here is not the kind of gold we often see, but the cannabinoids in plants, and its price is almost comparable to gold!

First of all, I would like to introduce industrial hemp to you. Industrial hemp refers to hemp with a tetrahydrocannabinol content of less than 0.3%. In China, industrial hemp is called hemp, which is an annual herb of the genus Cannabis in the family Cannabinaceae. Plants are divided into industrial hemp and drug marijuana, and the hemp widely used at home and abroad is industrial hemp. The powder made from the stalk core of industrial hemp, that is, the hemp stalk core ultrafine powder modified coating technology is applied to military uniforms, which can exert the high strength and high performance characteristics of the product.     

The industrial hemp that has been approved to be grown legally is a variety with low toxic content, and the THC value is lower than 0.3%. These industrial hemp (THC<0.3%) are considered to have no drug use value, but they are still a treasure, and their applications include at least textiles, paper, food, medicine, hygiene, daily chemicals, leather, automobiles, construction, decoration, packaging, etc. field. Is a classic production material.

As industrial hemp has gradually become an outlet in the capital market, business giants are scrambling to enter the market, and the value of industrial hemp extracts—cannabinoids—is rapidly being tapped. There are many kinds of cannabinoids and complex molecular structures. Extraction technology has become a technical barrier in the industrial hemp industry, and it is also the core weight of corporate strength and competitiveness.

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Cannabinoid refers to the active ingredient found in Cannabis cannabis, and its receptor system (endocannabinoid system) exists in both the nervous and immune systems of mammals. At present, there are more than 130 known cannabinoids, which are mainly divided into cannabidiol CBD, tetrahydrocannabinol THC, cannabinoid CBC, cannabinol CBN, cannabigerol CBG, etc.

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Taking CBD and THC as an example, the physical and chemical properties of the two are very close, and the extraction process is very difficult; in the CBD oil products that people often use, only 5%-19% of the active ingredients can be absorbed. In order to better realize the product use, the extraction method of cannabinoids is very important.

01How to extract cannabinoids?
CO2 Extraction
CO2 extraction is divided into supercritical, subcritical, and "medium critical" categories and does not involve the use of chemical solvents for the purpose of preserving CBD and other beneficial compounds.

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Carbon Dioxide Extraction
Solvent Extraction Solvent extraction
usually uses ethanol and butane as solvents to extract from cannabis plant excipients. The combination of the two works well, is simple and easy to operate, and can be operated at home. In the case of ensuring the extraction rate and purity, the method uses solvent extraction throughout the process, avoiding the use and residue of toxic organic solvents such as petroleum ether, and ensuring product safety.

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Solvent Extraction
Olive Oil Extraction
Heat the plant at a specific temperature for a period of time to activate the plant's chemicals, add olive oil, and heat for a period of time to finally obtain the cannabinoids.

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Olive Oil Extraction
Dry Ice Extraction
The marijuana plant is cut into chunks and placed in a bucket, covered with ice, inverted, and the mixture is filtered through a mesh bag several times to finally dry the extract until it becomes a powder. This method takes time and effort, but it can also be done at home.

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In addition to the dry ice extraction method
, there are many methods of obtaining cannabinoids such as cultivating genetically modified cannabis, biosynthesis and chemical synthesis. The above four methods are routinely used extraction methods.
The goal of cannabinoid extraction technology is to improve the extraction rate and purity of cannabinoids, remove THC residues as much as possible, avoid the use of toxic organic solvents as much as possible, ensure product safety and environmental protection, and reduce costs as much as possible. Among the current methods of obtaining cannabinoids, skilled extraction methods still occupy the mainstream position, and biosynthesis and chemical synthesis are the main directions for obtaining cannabinoids in the future.
02Are there any good or bad extraction techniques?
The extraction of cannabinoids goes through three steps: rough processing, fine processing and purification.
Rough processing refers to the extraction of all cannabinoids (including THC) from industrial hemp, commonly known as "crude extract", which cannot be used directly; filter the crude extract to filter out THC and other cannabinoids, and obtain precise cannabinoids according to demand , Refined cannabinoid products can basically meet the market demand; if you want to obtain a single product of cannabinoids with higher purity, you can perform purification operations, through the process of crystallization-purification-recrystallization-repurification, and finally obtain extremely high-purity cannabinoids single product.

The ancients said: If a worker wants to do a good job, he must first sharpen his tools. The rapid development of an industry is inseparable from the support of technology, especially efficient, green and sustainable technology. For example, in the industrial hemp extraction industry, excellent extraction technology is required. Innovative Tongheng's HPLC technology provides a good solution for the rapid extraction of industrial hemp.

Since its establishment in 2000, Xinxintongheng people have adhered to the spirit of innovation and continuous improvement, adhering to the corporate development tenet of "taking liquid chromatography technology as the core, continuously expanding application fields, and meeting different needs of customers", Overcoming one technical difficulty after another, in the field of chromatographic products, it has become one of the largest research and manufacturing enterprises in China.

 

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Equipment introduction:

The industrial HPLC purification system adopts explosion-proof design, the explosion-proof grade is Exd II B T4, the system can support chromatographic columns of 300~1200mm, and the infusion pump 500mL/min~50L/min is optional

Features:

1. The system adopts DAC chromatographic column, and pushes the piston to pack the column through the hydraulic cylinder

2. The system adopts "H-TREE" distribution technology (invention patent: 2009101700132) to solve the problem of sample distribution of large diameter chromatographic columns

3. The system adopts optical fiber flow cell technology, which is suitable for explosion-proof occasions, but the detector and flow cell are separated

4. Fully comply with FAD and cGMP certification requirements, and provide a full set of documents and services that meet regulatory requirements

 

 

 

Equipment introduction:

Integrated appearance design, open and concise, H-TREE (patent number: 2009101700132) unique high-efficiency forced distribution method ensures separation effect and stability, new hydraulic design scheme, reduces equipment height (within 2.5m) Equipment weight, easy to maintain.

Equipment introduction:

The system includes column packing unit, mobile phase transmission unit, ultraviolet detection and fraction collection unit (semi-automatic or fully automatic), control unit (computer, electric control cabinet) and other necessary related equipment and accessories. It is suitable for use in flammable and explosive environments. It has built-in multiple operating modes, high degree of automation, and integrates various system protection measures.

"Go all out in everything, always be grateful" is the motto that Chuangxin Tongheng people are proud of. After ten years of hard work, the company has developed into a company with hundreds of employees and a production and office area of ​​more than 6,000 square meters. m medium-sized enterprises. Products include laboratory high-performance liquid chromatography systems, pilot-scale preparative liquid chromatography systems, and production-type industrial preparative liquid chromatography systems; the product line runs through the entire process of quality inspection, research and development, and large-scale production in the fields of medicine and chemical industry. While providing a full set of hardware equipment, Innovation Tongheng also has a pilot plant for separation and purification process research, which can provide customers with the best overall solution.

Over the years, the company has focused on enterprise construction and technology accumulation, successively introduced modern management methods such as ERP, CRM, and OA, and passed ISO9001:2000 enterprise management system certification, and some products have passed EU CE certification; the company has more than 20 inventions and utility models Patents and software copyrights; won gold awards for independent innovation of scientific instruments for many times; successively undertook major national new drug creation projects during the 11th Five-Year Plan; in national special support projects, received special funds such as energy conservation and emission reduction, innovation funds, etc., and was continuously rated as Zhongguancun Gazelle Enterprise, national high-tech enterprise.